Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7 (1-piperazinyl) quinoline-3-carboxylic acid derivatives

Z Yu, G Shi, Q Sun, H Jin, Y Teng, K Tao, G Zhou…

文献索引：Yu, Zhiyi; Shi, Guanying; Sun, Qiu; Jin, Hong; Teng, Yun; Tao, Ke; Zhou, Guoping; Liu, Wei; Wen, Fang; Hou, Taiping European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4726 - 4733

全文：HTML全文

被引用次数: 25

摘要

A series of 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7 (1-piperazinyl) quinoline-3-carboxylic acid (norfloxacin) derivatives were prepared according to the principle of combinating bioactive substructures and tested for their activities against five plant pathogenic bacteria and three fungi in vitro. The preliminary bioassays indicated that almost all synthesized target compounds retained the antibacterial activities of norfloxacin and had some antifungal ...