Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

MC O'Sullivan, Q Zhou, Z Li, TB Durham…

文献索引：O'Sullivan, Mary C.; Zhou, Qibing; Li, Zhili; Durham, Timothy B.; Rattendi, Donna; Lane, Schennella; Bacchi, Cyrus J. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2145 - 2155

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被引用次数: 54

摘要

Trypanothione reductase (TR) occurs exclusively in trypanosomes and leishmania, which are the etiological agents of many diseases. TR plays a vital role in the antioxidant defenses of these parasites and inhibitors of TR have potential as antitrypanosomal agents. We describe the syntheses of several spermine and spermidine derivatives and the inhibiting effects of these compounds on T. cruzi TR. All of the inhibiting compounds displayed ...