Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-. beta.-D-arabinofuranosyl) cytosines and-uracils. Some structure-activity …

KA Watanabe, TL Su, RS Klein, CK Chu…

文献索引：Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156

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被引用次数: 122

摘要

Conclusions The results of this study suggest that reasonable in vitro and in vivo protection against soman and paraoxon poisoning is provided by the newly designed cyclic phosphate ester via the reversible masking of AChE by covalent phosphorylation. Effective pretreatment was dependent on subsequent treatment with cholinolytics and TMB-4. The successful use of car barn ate^^^^*^^ or TEPPlO as pretreatment against organophosphate poisoning ...