Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-. beta.-D-arabinofuranosyl) cytosines and-uracils. Some structure-activity …

KA Watanabe, TL Su, RS Klein, CK Chu…

Index: Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156

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Citation Number: 122

Abstract

Conclusions The results of this study suggest that reasonable in vitro and in vivo protection against soman and paraoxon poisoning is provided by the newly designed cyclic phosphate ester via the reversible masking of AChE by covalent phosphorylation. Effective pretreatment was dependent on subsequent treatment with cholinolytics and TMB-4. The successful use of car barn ate^^^^*^^ or TEPPlO as pretreatment against organophosphate poisoning ...

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