Xanthocyclines: 5-oxaanthracyclines (7, 8, 9, 10-tetrahydrobenzo [b] xanthen-12-one)

JL Charlton, VA Sayeed…

文献索引：Charlton, James L.; Sayeed, Vilayat A.; Lypka, Gerald N. Canadian Journal of Chemistry, 1982 , vol. 60, p. 1996 - 2001

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被引用次数: 6

摘要

The anthracycline antibiotics daunorubicin and adriamycin are potent antitumor agents. It has recently been suggested that 5-oxaanthracycline analogs of these compounds might show reduced cardiotoxicity, a property that limits the clinical use of the anthracyclines. In this paper we describe the condensation-cyclization reactions of 2-methylchromone-3- carboxylate with cyclohexanones, a reaction that leads ultimately to the xanthocycline ...