Chemical communications

Contra-Friedel–Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

J Clayden, CC Stimson, M Keenan

文献索引：Clayden, Jonathan; Stimson, Christopher C.; Keenan, Martine Chemical Communications, 2006 , # 13 p. 1393 - 1394

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被引用次数: 13

摘要

Directed metallation and sulfinylation yields sulfoxides which undergo ipso nucleophilic aromatic substitution with tertiary and secondary alkyllithiums, giving aromatic rings bearing alkyl groups generally incompatible with directed metallation methods and with regioselectivity complementary with classical Friedel–Crafts substitution.