Silica gel as an effective catalyst for the alkylation of phenols and some heterocyclic aromatic compounds

Y Kamitori, M Hojo, R Masuda, T Izumi…

文献索引：Kamitori, Yasuhiro; Hojo, Masaru; Masuda, Ryoichi; Izumi, Tatsuo; Tsukamoto, Shuichi Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4161 - 4165

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被引用次数: 66

摘要

In the presence of silica gel, the reaction of phenol with t-BuBr was examined under a variety of conditions and it was found that silica gel is an effective catalyst for the alkylation. As a result of this work 2-tert-butyl-, 2, 6-di-tert-butyl-, and 2, 4, 6-tri-tert-butylphenols, all of which are hard to obtain directly by the Friedel-Crafts process, could be prepared easily by this one- step reaction. Several other alkyl halides were also used in this reaction. The alkylations ...