4-Hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites …

…, J Schmidt, M Pleiss, E Wagner, JK Baker

文献索引：Coats; Shah; Milstein; Genther; Nene; Roesener; Schmidt; Pleiss; Wagner; Baker Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 57 - 63

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被引用次数: 23

摘要

The compounds were evaluated against four isolated enzyme systems: glyceraldehyde-3- phosphate dehydrogenase and lactate dehydrogenase from cytoplasmic glycolysis, and glutamate dehydrogenase and malate dehydrogenase from the mitochondria. Correlation analyses of the data were reported by Hansch and Yoshimoto7 and supported the qualitative assessment of Baker that hydrophobic groups substituted at the 5 position of ...