Ruthenium??Catalyzed Synthesis of Indoles from Anilines and Epoxides

M Peña??López, H Neumann…

文献索引：Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1818 - 1824

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被引用次数: 15

摘要

Abstract A general synthetic route to indoles from readily available anilines and epoxides by using ruthenium catalysis is described. This straightforward transformation allows a variety of indoles to be obtained in good yields by using [Ru 3 (CO) 12]/1, 1′-bis (diphenylphosphino) ferrocene as the catalytic system. Water and hydrogen are formed as the only stoichiometric by-products, making this process highly atom efficient.

~49%

~75%

~70%

~46%

~60%

~63%

~65%

~52%

~78%

~75%

~84%

~82%

~75%

~88%

~85%

~77%

~79%

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