One??pot??one??step, microwave??assisted Fischer indole synthesis

…, M Tsukamoto, T Horaguchi

文献索引：Creencia, Evelyn Cuevas; Tsukamoto, Masayuki; Horaguchi, Takaaki Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1095 - 1102

全文：HTML全文

被引用次数: 19

摘要

Abstract The Fischer indole synthesis was carried out using microwaves instead of conventional heating procedures. When the mixture of phenylhydrazine, cyclohexanone and zinc chloride was irradiated at 600 W for 3 min, 76% of 1, 2, 3, 4-tetrahydrocarbazole was obtained. However, when zinc chloride was replaced with p-toluenesulfonic acid (p-TSA), the reaction yielded 91% of 1, 2, 3, 4-tetrahydrocarbazole. Thus, a series of indoles were ...