Molecular modification of anticholinergics as probes for muscarinic receptors. 1. Amino esters of. alpha.-substituted phenylacetic acid and related analogs

…, S Callejas, JE Gearien, EB Thompson

文献索引：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

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被引用次数: 18

摘要

Two series of compounds having the general structure of C6H&RR'COOCH2CH, NE& were synthesized and examined for their antispasmodic activities. These compounds were selected as structural probes for exploring the nature of muscarinic cholinergic receptor binding sites that interact with atropine-like anticholinergics. These studies indicate a rather strict size limitation for the hydrophobic region of the receptor and suggest intramolecular ...