Microbial Baeyer–Villiger oxidation of steroidal ketones using Beauveria bassiana: presence of an 11α-hydroxyl group essential to generation of D-homo lactones

A Świzdor, T Kołek, A Panek, A Białońska

文献索引：Swizdor, Alina; Kolek, Teresa; Panek, Anna; Bialonska, Agata Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2011 , vol. 1811, # 4 p. 253 - 262

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被引用次数: 22

摘要

This paper demonstrates for the first time transformation of a series of 17-oxo steroidal substrates (epiandrosterone, dehydroepiandrosterone, androstenedione) by the most frequently used whole cell biocatalyst, Beauveria bassiana, to 11α-hydroxy-17a-oxa-d-homo- androst-17-one products, in the following sequence of reactions: 11α-hydroxylation and subsequent Baeyer–Villiger oxidation to a ring-D lactone. 11α-Hydroxyprogesterone, the ...