Steroids

Microbial transformation of androst-4-ene-3, 17-dione by Beauveria bassiana

Z Xiong, Q Wei, H Chen, S Chen, W Xu, G Qiu, S Liang…

文献索引：Xiong, Zhigang; Wei, Qi; Chen, Hanmei; Chen, Shouwen; Xu, Wenjin; Qiu, Guofu; Liang, Shucai; Hu, Xianming Steroids, 2006 , vol. 71, # 11-12 p. 979 - 983

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被引用次数: 34

摘要

The microbial transformation of androst-4-ene-3, 17-dione (I) by the fungus Beauveria bassiana CCTCC AF206001 has been investigated using pH 6.0 and 7.0 media. Two hydroxylated metabolites were obtained with the pH 6.0 medium. The major product was 11α-hydroxyandrost-4-ene-3, 17-dione (II) whereas the minor product was 6β, 11α- dihydroxyandrost-4-ene-3, 17-dione (III). On the other hand, four hydroxylated and/or ...