Benzhydrylamine linker grafting: a strategy for the improved synthesis of C??terminal peptide amides

D Alewood, G Hopping, A Brust…

文献索引：Alewood, Dianne; Hopping, Gene; Brust, Andreas; Reid, Robert C.; Alewood, Paul F. Journal of Peptide Science, 2010 , vol. 16, # 10 p. 551 - 557

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被引用次数: 7

摘要

Abstract The standard p-MBHA resin used during Boc-chemistry synthesis of peptides carrying C-terminal carboxamides is compromised by batch-to-batch variations in its performance. This can cause artificially 'difficult'couplings during peptide chain assembly, which may ultimately lead to failed syntheses given the inability to achieve acceptable coupling yields. To overcome these problems, we have developed a new approach by ...