Tetrahedron letters

Synthesis of a thioester linker precursor for a general preparation of peptide C-terminal thioacids

H Gaertner, M Villain, P Botti, L Canne

文献索引：Gaertner, Hubert; Villain, Matteo; Botti, Paolo; Canne, Lynne Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2239 - 2241

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被引用次数: 11

摘要

A general procedure to prepare peptide thioacids by solid-phase peptide synthesis is presented. The method involves the synthesis of 4-[α-(S-acetyl) mercaptobenzyl] phenoxyacetic acid as general precursor. This reagent once attached to a solid support is derivatized with the Boc-amino acid of choice after deprotection of the thiol.