Scale-up of the green synthesis of azacycloalkanes and isoindolines under microwave irradiation

TM Barnard, GS Vanier, MJ Collins

文献索引：Barnard, T. Michael; Vanier, Grace S.; Collins Jr., Michael J. Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1233 - 1237

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被引用次数: 28

摘要

A green approach to N-heterocyclization reactions ranging in scale from 20 mmol to 1 mol performed under microwave irradiation in open vessels has been investigated. By using water as the solvent and no transition metal catalysts, N-heterocycles are formed in a fraction of the time needed for conventional synthesis of these compounds. The obtained yields indicate that reactions can be performed at atmospheric pressure using the same ...