An efficient method for the synthesis of 2, 3-dihydro-1H-isoindoles

A Subbarayappa, PU Patoliya

文献索引：Subbarayappa, Adimurthy; Patoliya, Paresh U. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 545 - 552

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被引用次数: 5

摘要

Abstract: The synthesis of N-substituted 2, 3-dihydro-1H-isoindoles from⍺,⍺'-dibromo-o- xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1, 4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the ...