Biochemistry

Complex Formation of Amphotericin B in Sterol-Containing Membranes As Evidenced by Surface Plasmon Resonance†

R Mouri, K Konoki, N Matsumori, T Oishi, M Murata

文献索引：Matsumori, Nobuaki; Yamaji, Nahoko; Matsuoka, Shigeru; Oishi, Tohru; Murata, Michio Journal of the American Chemical Society, 2002 , vol. 124, # 16 p. 4180 - 4181

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被引用次数: 40

摘要

Amphotericin B (AmB) is a membrane-active antibiotic that increases the permeability of fungal membranes. Thus, the dynamic process of its interaction with membranes poses intriguing questions, which prompted us to elaborate a quick and reliable method for real- time observation of the drug's binding to phospholipid liposomes. We focused on surface plasmon resonance (SPR) and devised a new modification method of sensor chips, which ...