Journal of medicinal chemistry

Structural Studies on Bioactive Compounds. 32. 1 Oxidation of Tyrphostin Protein Tyrosine Kinase Inhibitors with Hypervalent Iodine Reagents

G Wells, A Seaton, MFG Stevens

文献索引：Wells, Geoffrey; Seaton, Angela; Steven, Malcolm F. G. Journal of Medicinal Chemistry, 2000 , vol. 43, # 8 p. 1550 - 1562

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被引用次数: 46

摘要

Hydroxylated styrenes (tyrphostins) undergo oxidation by hypervalent iodine oxidants such as [(diacetoxy) iodo] benzene (DAIB) to give a range of products depending on the structure of the phenolic substrate, the solvent, the oxidant stoichiometry, and the purification strategy. Conditions have been developed to modify the phenolic component of the tyrphostin without affecting the appended substituted-vinyl moiety. Novel products include: unstable 2- ...