前往化源商城

Tetrahedron

Titanium-induced syntheses of furans, benzofurans and indoles

A Fürstner, DN Jumbam

文献索引:Fuerstner, Alois; Jumbam, Denis N. Tetrahedron, 1992 , vol. 48, # 29 p. 5991 - 6010

全文:HTML全文

被引用次数: 117

摘要

Highly reactive titanium on graphite as the reagent of choice promotes intramolecular McMurry type reactions of acyloxy-and acylamido carbonyl compounds affording furans, benzofurans and indoles in good to excellent yields. A variety of reducible groups in the substrates is tolerated (eg-F,-Cl,-Br,-I,-CF3,-OMe,-CN,-thiophenyl,-COOR,-CONR2) and strained products such as 11h can be obtained, the X-ray analysis of which is reported. ...

 相关合成线路

~90%

~89%

~89%

~%

~86%

~85%

~70%

~96%

~%

~88%

~76%

~92%

~%

~91%

~%

~83%

~92%

~85%

~%

~74%

~70%