Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents

R Bairwa, M Kakwani, NR Tawari, J Lalchandani…

文献索引：Bairwa, Ranjeet; Kakwani, Manoj; Tawari, Nilesh R.; Lalchandani, Jaya; Ray; Rajan; Degani, Mariam S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1623 - 1625

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被引用次数: 47

摘要

In an attempt to identify potential new agents active against tuberculosis, 20 novel phenylacrylamide derivatives incorporating cinnamic acids and guanylhydrazones were synthesized using microwave assisted synthesis. Activity of the synthesized compounds was evaluated using resazurin microtitre plate assay (REMA) against Mycobacterium tuberculosis H37Rv. Based on empirical structure–activity relationship data it was ...