Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents

R Bairwa, M Kakwani, NR Tawari, J Lalchandani…

Index: Bairwa, Ranjeet; Kakwani, Manoj; Tawari, Nilesh R.; Lalchandani, Jaya; Ray; Rajan; Degani, Mariam S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1623 - 1625

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Citation Number: 47

Abstract

In an attempt to identify potential new agents active against tuberculosis, 20 novel phenylacrylamide derivatives incorporating cinnamic acids and guanylhydrazones were synthesized using microwave assisted synthesis. Activity of the synthesized compounds was evaluated using resazurin microtitre plate assay (REMA) against Mycobacterium tuberculosis H37Rv. Based on empirical structure–activity relationship data it was ...