Tetrahedron

N-Nosyl-α-amino acids in solution phase peptide synthesis

A Leggio, ML Di Gioia, F Perri, A Liguori

文献索引：Leggio, Antonella; Di Gioia, Maria Luisa; Perri, Francesca; Liguori, Angelo Tetrahedron, 2007 , vol. 63, # 34 p. 8164 - 8173

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被引用次数: 11

摘要

A highly efficient and practical synthesis of peptides in solution phase has been developed. The procedure is based on the use of p-nitrobenzenesulfonyl (nosyl) group for the protection of the amino function of α-amino acids. Every step of the procedure, protection of the amino function by the nosyl group, formation of the peptide bond, and removal of the sulfonamide group, is characterized by high yields and excellent purity of the final products. The ...