One-Pot Multicomponent Michael and Thorpe–Ziegler Reaction of Aryl Methyl Ketones

V Jaitak, Bandna, P Das, VK Kaul, B Singh…

文献索引：Jaitak, Vikas; Bandna; Das, Pralay; Kaul; Singh, Bikram; Kumar, Neeraj Synthetic Communications, 2011 , vol. 41, # 18 p. 2727 - 2737

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摘要

Abstract A regioselective base-promoted Michael and Thorpe–Ziegler reaction between aryl methyl ketones and α, β-unsaturated nitrile was carried out in a single step. Different functional groups in addition to active positions were tolerated under this condition. Results indicated that the reaction proceeds in a consecutive manner as double Michael, triple Michael, and Thorpe–Ziegler condensation. By applying click chemistry, double Michael ...