Astragaloside VI

Modify Date: 2024-01-01 18:38:40

Astragaloside VI Structure
Astragaloside VI structure
Common Name Astragaloside VI
CAS Number 84687-45-6 Molecular Weight 947.11100
Density N/A Boiling Point N/A
Molecular Formula C47H78O19 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Astragaloside VI


Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing.

 Names

Name astragaloside VI
Synonym More Synonyms

 Astragaloside VI Biological Activity

Description Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing.
Related Catalog
Target

EGFR

In Vitro Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells[1]. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades[2].
In Vivo Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models[1]. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats[2].
References

[1]. Lee SY, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018 Jan 1;38:183-191.

[2]. Chen X, et al. Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades. Mol Neurobiol. 2018 Aug 7.

 Chemical & Physical Properties

Molecular Formula C47H78O19
Molecular Weight 947.11100
Exact Mass 946.51400
PSA 307.37000
Storage condition 2-8°C

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

MFCD17214426
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