Astragaloside II

Modify Date: 2024-01-02 09:34:51

Astragaloside II Structure
Astragaloside II structure
Common Name Astragaloside II
CAS Number 84676-89-1 Molecular Weight 827.01
Density 1.4±0.1 g/cm3 Boiling Point 896.9±65.0 °C at 760 mmHg
Molecular Formula C43H70O15 Melting Point N/A
MSDS Chinese USA Flash Point 265.3±27.8 °C

 Use of Astragaloside II


Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].

 Names

Name Astragaloside II
Synonym More Synonyms

 Astragaloside II Biological Activity

Description Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].
Related Catalog
References

[1]. Haijun Qu, et al. Quantification and pharmacokinetics of astragaloside II in rats by rapid liquid chromatography-tandem mass spectrometry. Anal. Methods, 2014,6, 6815-6822

[2]. Kong XH, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. Int J Mol Med. 2012 Jun;29(6):1090-8.

[3]. Huang C, et al. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. J Pharm Pharmacol. 2012 Dec;64(12):1741-50.

[4]. Wan CP, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 2013 Apr;34(4):522-30.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 896.9±65.0 °C at 760 mmHg
Molecular Formula C43H70O15
Molecular Weight 827.01
Flash Point 265.3±27.8 °C
PSA 234.29000
LogP 0.80
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.615

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
HS Code 29389090

 Precursor & DownStream

Precursor  0

DownStream  2

 Synonyms

β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-3-[(2-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-14-methyl-9,19-cyclocholestan-6-yl
Cyclosieversioside D
(3β,6α,16β,20R,24S)-3-[(2-O-Acetyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-14-methyl-20,24-epoxy-9,19-cyclocholestan-6-yl β-D-glucopyranoside
AstrasieversianinVIII
16,25-dihydroxy-9,19-cyclolanostan-6-yl
Astragaloside B
Cyclosiversioside D
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