1, 2-Didemethylcolchicine

Modify Date: 2024-01-10 12:10:06

1, 2-Didemethylcolchicine Structure
1, 2-Didemethylcolchicine structure
Common Name 1, 2-Didemethylcolchicine
CAS Number 78231-83-1 Molecular Weight 371.38400
Density 1.38g/cm3 Boiling Point 783.5ºC at 760 mmHg
Molecular Formula C20H21NO6 Melting Point N/A
MSDS N/A Flash Point 427.6ºC

 Names

Name N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.38g/cm3
Boiling Point 783.5ºC at 760 mmHg
Molecular Formula C20H21NO6
Molecular Weight 371.38400
Flash Point 427.6ºC
Exact Mass 371.13700
PSA 105.09000
LogP 2.65650
Index of Refraction 1.642

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8585500
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-
CAS REGISTRY NUMBER :
78231-83-1
LAST UPDATED :
198912
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N-O6
MOLECULAR WEIGHT :
371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
167 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

 Synthetic Route

~25%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

~27%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

~%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

~%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

 Synonyms

Acetamide,N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)
1,2-Didemethylcolchicine
Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)
1,2-O-didemethylcolchicine