Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Modify Date: 2024-03-04 09:19:53

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]- structure	Common Name	Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-
	CAS Number	57866-21-4	Molecular Weight	371.38400
	Density	1.38g/cm3	Boiling Point	810.3ºC at 760mmHg
	Molecular Formula	C₂₀H₂₁NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	443.9ºC

Name	Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)
Synonym	More Synonyms

Density	1.38g/cm3
Boiling Point	810.3ºC at 760mmHg
Molecular Formula	C₂₀H₂₁NO₆
Molecular Weight	371.38400
Flash Point	443.9ºC
Exact Mass	371.13700
PSA	105.09000
LogP	2.65650
Index of Refraction	1.642

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8585750

CHEMICAL NAME :: Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-

CAS REGISTRY NUMBER :: 57866-21-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N-O6

MOLECULAR WEIGHT :: 371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJCIB8 European Journal of Clinical Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1970- Volume(issue)/page/year: 22,630,1992

Desmethylcolchicine

CAS#:7336-33-6

Acetamide,N-[(7...

CAS#:57866-21-4

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

3-ethoxycarbony...

CAS#:123417-71-0

~30%

Acetamide,N-[(7...

CAS#:57866-21-4

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

Colchicine

CAS#:64-86-8

~7%

2-demethylcolchicine

CAS#:7336-36-9

Acetamide,N-[(7...

CAS#:57866-21-4

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

Precursor 2
CAS#:7336-33-6 Desmethylcolchicine CAS#:64-86-8 Colchicine
DownStream 1
CAS#:6877-25-4 Cornigerine

2,3-O-didemethylcolchicine

(S)-7-(Acetylamino)-6,7-dihydro-1,10-dimethoxy-2,3-dihydroxybenzo[a]heptalen-9(5H)-one

2,3-Didemethylcolchicin

2,3-Dimethylcolchicine

2,3-didemethylcolchicine

Dichloromethane
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Polyacrylic acid
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sodium carbonate
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Silicon dioxide
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Triethanolamine
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Demeton
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4-(4-Piperidinyl)morpholine dihydrochloride
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Diclofenac sodium
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Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms