Desmethylcolchicine

Modify Date: 2024-01-07 21:32:45

Desmethylcolchicine structure	Common Name	Desmethylcolchicine
	CAS Number	7336-33-6	Molecular Weight	357.40000
	Density	1.31g/cm3	Boiling Point	768.3ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₃NO₅	Melting Point	163-166ºC
	MSDS	N/A	Flash Point	418.5ºC

Use of Desmethylcolchicine

3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].

Name	N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym	More Synonyms

Description	3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117. [2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

Description

3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].

Related Catalog

Research Areas >> Inflammation/Immunology

References

[1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.

[2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

Density	1.31g/cm3
Boiling Point	768.3ºC at 760 mmHg
Melting Point	163-166ºC
Molecular Formula	C₂₀H₂₃NO₅
Molecular Weight	357.40000
Flash Point	418.5ºC
Exact Mass	357.15800
PSA	84.86000
LogP	3.15700
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0880500

CHEMICAL NAME :: Colchicine, 3-O-demethyl-

CAS REGISTRY NUMBER :: 7336-33-6

LAST UPDATED :: 199112

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EQ JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Hazard Codes	Xi

Colchicoside

CAS#:477-29-2

~89%

Desmethylcolchicine

CAS#:7336-33-6

Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

Colchicine

CAS#:64-86-8

Desmethylcolchicine

CAS#:7336-33-6

Literature: Maier, Ulrich H.; Zenk, Meinhart H. Tetrahedron Letters, 1997 , vol. 38, # 42 p. 7357 - 7360

Precursor 2
CAS#:477-29-2 Colchicoside CAS#:64-86-8 Colchicine
DownStream 3
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