chlorquinaldol

Modify Date: 2024-01-04 18:29:42

chlorquinaldol Structure
chlorquinaldol structure
Common Name chlorquinaldol
CAS Number 72-80-0 Molecular Weight 228.075
Density 1.5±0.1 g/cm3 Boiling Point 350.7±37.0 °C at 760 mmHg
Molecular Formula C10H7Cl2NO Melting Point 108-112 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 165.9±26.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of chlorquinaldol


Chlorquinaldol is a mono-hydroxyquinoline, is an antifungal and antibacterial, used for topical treatment of skin conditions and vaginal infections.

 Names

Name chlorquinaldol
Synonym More Synonyms

 chlorquinaldol Biological Activity

Description Chlorquinaldol is a mono-hydroxyquinoline, is an antifungal and antibacterial, used for topical treatment of skin conditions and vaginal infections.
Related Catalog

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 350.7±37.0 °C at 760 mmHg
Melting Point 108-112 °C (dec.)(lit.)
Molecular Formula C10H7Cl2NO
Molecular Weight 228.075
Flash Point 165.9±26.5 °C
Exact Mass 226.990463
PSA 33.12000
LogP 4.21
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.679
Storage condition 2-8°C
Water Solubility Insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC5600000
CHEMICAL NAME :
8-Quinolinol, 5,7-dichloro-2-methyl-
CAS REGISTRY NUMBER :
72-80-0
BEILSTEIN REFERENCE NO. :
0156683
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H7-Cl2-N-O
MOLECULAR WEIGHT :
228.08
WISWESSER LINE NOTATION :
T66 BNJ C1 GG IG JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION :
1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S36/37/39
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS VC5600000
HS Code 2933499090

 Synthetic Route

~62%

chlorquinaldol Structure

chlorquinaldol

CAS#:72-80-0

Literature: Organic Letters, , vol. 16, # 3 p. 864 - 867

~%

chlorquinaldol Structure

chlorquinaldol

CAS#:72-80-0

Literature: CH229982 , ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles26

More Articles
Purity determination of gynalgin bactericidal tablets with HPLC method.

Acta Pol. Pharm. 70(1) , 51-8, (2013)

The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6...

[Allergies to 8-hydroxyquinoline derivatives].

Derm. Beruf Umwelt. 36(3) , 86-90, (1988)

Evaluation of our standardized test results from 1972 to 1983 indicated Vioform allergies in 1.2% of all cases and Sterosan allergies in 1.1%. Our results are within the spectrum found in the literatu...

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Antimicrob. Agents Chemother. 51 , 1105-6, (2007)

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/...

 Synonyms

5,7-Dichloro-2-methyl-8-quinolinol
5,7-Dichloro-8-hydroxyquinaldine
2-methyl-5,7-dichloro-8-hydroxyquinoline
5,7-Dichloro-8-quinaldinol
Clorquinaldol
Chloroquinaldol
EINECS 200-789-3
Gynotherax
5,7-dichloro-2-methylquinolin-8-ol
2-methylchloroxine
5,7-Dichlor-2-methylchinolin-8-ol
Saprosan
Sterosan
5,7-dichloro-2-methyl-8-hydroxy-quinoline
8-Quinolinol, 5,7-dichloro-2-methyl-
chlorquinaldol
Chlorchinaldolum
Chlorquinaldolum
MFCD00023984
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