Thiol-C2-PEG2-OH
Modify Date: 2024-01-05 20:35:06
Thiol-C2-PEG2-OH structure
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Common Name | Thiol-C2-PEG2-OH | ||
|---|---|---|---|---|
| CAS Number | 56282-36-1 | Molecular Weight | 166.23900 | |
| Density | 1.094g/cm3 | Boiling Point | 270.3ºC at 760 mmHg | |
| Molecular Formula | C6H14O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 117.3ºC | |
Use of Thiol-C2-PEG2-OHThiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 3,6-Dioxa-8-mercaptooctan-1-ol |
|---|---|
| Synonym | More Synonyms |
| Description | Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] |
| References |
| Density | 1.094g/cm3 |
|---|---|
| Boiling Point | 270.3ºC at 760 mmHg |
| Molecular Formula | C6H14O3S |
| Molecular Weight | 166.23900 |
| Flash Point | 117.3ºC |
| Exact Mass | 166.06600 |
| PSA | 77.49000 |
| Index of Refraction | 1.475 |
|
~80%
Thiol-C2-PEG2-OH CAS#:56282-36-1 |
| Literature: Boden, Neville; Bushby, Richard J.; Liu, Quanying; Evans, Stephen D.; Toby; Jenkins; Knowles, Peter F.; Miles, Robert E. Tetrahedron, 1998 , vol. 54, # 38 p. 11537 - 11548 |
|
~84%
Thiol-C2-PEG2-OH CAS#:56282-36-1 |
| Literature: Asseline; Bonfils; Kurfurst; Chassignol; Roig; Thuong Tetrahedron, 1992 , vol. 48, # 7 p. 1233 - 1254 |
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~%
Thiol-C2-PEG2-OH CAS#:56282-36-1 |
| Literature: Hutchison, James E.; Woehrle, Gerd H.; Warner, Marvin G.; Brown, Leif O. Patent: US2009/99044 A1, 2009 ; |
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~%
Thiol-C2-PEG2-OH CAS#:56282-36-1 |
| Literature: Conte, Mauro Lo; Robb, Maxwell J.; Hed, Yvonne; Marra, Alberto; Malkoch, Michael; Hawker, Craig J.; Dondoni, Alessandro Journal of Polymer Science, Part A: Polymer Chemistry, 2011 , vol. 49, # 20 p. 4468 - 4475 |
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~%
Thiol-C2-PEG2-OH CAS#:56282-36-1 |
| Literature: Charvet, Nicolas; Reiss, Peter; Roget, Andre; Dapuis, Alain; Gruenwald, Didier; Carayon, Sophie; Chandezon, Frederic; Livache, Thierry Journal of Materials Chemistry, 2004 , vol. 14, # 17 p. 2638 - 2642 |
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| Precursor 2 | |
|---|---|
| DownStream 1 | |
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CAS#:97463-42-8| 2-[2-(2-sulfanylethoxy)ethoxy]ethanol |