AKT-IN-12

Modify Date: 2024-01-09 19:21:06

AKT-IN-12 structure	Common Name	AKT-IN-12
	CAS Number	2396718-52-6	Molecular Weight	722.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₄₆N₂O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AKT-IN-12

AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].

Name	AKT-IN-12

Description	AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	IC50: 0.55 μM (Akt)[1]
References	[1]. Yang J, et al. Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway. Eur J Med Chem. 2020;186:111898.

Molecular Formula	C₄₂H₄₆N₂O₇S
Molecular Weight	722.89

AKT-IN-12

Use of AKT-IN-12

Names

AKT-IN-12 Biological Activity

Chemical & Physical Properties