1295514-91-8

1295514-91-8 structure

1295514-91-8 structure

Name: AKT-IN-2
Chemical Name: AKT-IN-2
CAS Number: 1295514-91-8
Molecular Formula: C₂₅H₃₄F₃N₇O
Molecular Weight: 505.58
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2019-03-30 13:17:34
Modify Date: 2024-01-23 20:53:09
AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].

Name	AKT-IN-2

Description	AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:5 nM (IC50) P70S6K:399 nM (IC50) PKA:84 nM (IC50) PKCβ2:3.98 μM (IC50) RSK1:568 nM (IC50) pGSK3β:92 nM (IC50)
In Vitro	AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC50s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively[1].
References	[1]. Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891.

Molecular Formula	C₂₅H₃₄F₃N₇O
Molecular Weight	505.58