AKT-IN-12

Names

[ CAS No. ]:
2396718-52-6

[ Name ]:
AKT-IN-12

Biological Activity

[Description]:

AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

IC50: 0.55 μM (Akt)[1]


[References]

[1]. Yang J, et al. Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway. Eur J Med Chem. 2020;186:111898.

Chemical & Physical Properties

[ Molecular Formula ]:
C42H46N2O7S

[ Molecular Weight ]:
722.89

Related Compounds