RIP2 kinase inhibitor 1

Modify Date: 2024-01-08 20:22:26

RIP2 kinase inhibitor 1 structure	Common Name	RIP2 kinase inhibitor 1
	CAS Number	2380028-10-2	Molecular Weight	355.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₇N₅O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].

Name	RIP2 kinase inhibitor 1

Description	RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	IC50: 0.03 μM (RIP2)[1]
In Vitro	RIP2 kinase inhibitor 1 (compound 11) inhibits human whole blood (hWB; IC50=0.05 μM), activin receptor-like kinase 5 (ALK5; IC50>10 μM), VEGFR2 (IC50=7.94 μM), lymphocyte-specific protein tyrosine kinase (LCK; IC50=31.6 μM)[1].
References	[1]. Haffner CD, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.ACS Med Chem Lett. 2019 Oct 11;10(11):1518-1523.

Molecular Formula	C₁₇H₁₇N₅O₂S
Molecular Weight	355.41

DC Chemicals Limited
China
Product Name: RIP2 kinase inhibitor 1
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Purity: 98.0%
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