Tetraethylene glycol monomethyl ether

Modify Date: 2024-01-02 10:45:34

Tetraethylene glycol monomethyl ether Structure
Tetraethylene glycol monomethyl ether structure
Common Name Tetraethylene glycol monomethyl ether
CAS Number 23783-42-8 Molecular Weight 208.252
Density 1.0±0.1 g/cm3 Boiling Point 285.4±25.0 °C at 760 mmHg
Molecular Formula C9H20O5 Melting Point N/A
MSDS Chinese USA Flash Point 126.4±23.2 °C

 Use of Tetraethylene glycol monomethyl ether


Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Tetraethylene glycol monomethyl ether Biological Activity

Description Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 285.4±25.0 °C at 760 mmHg
Molecular Formula C9H20O5
Molecular Weight 208.252
Flash Point 126.4±23.2 °C
Exact Mass 208.131073
PSA 57.15000
LogP -1.87
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.436

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
HS Code 2909499000

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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 Synonyms

Tetraethyleneglycol monomethyl ether
MFCD00041756
2,5,8,11-Tetraoxatridecan-13-ol
3,6,9,12-tetraoxatridecan-1-ol
Methyl Tetraglycol
3,6,9,12-tetraoxatridecanol
DSSTox_CID_7829
Tetraethylene Glycol MonoMethyl Ether
EINECS 245-883-5
AmbotzPEG2155
methyltetraglycol
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