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23778-52-1

23778-52-1 structure
23778-52-1 structure
  • Name: Pentaethylene glycol monomethyl ether
  • Chemical Name: 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
  • CAS Number: 23778-52-1
  • Molecular Formula: C11H24O6
  • Molecular Weight: 252.305
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-18 23:18:26
  • Modify Date: 2024-01-05 11:46:22
  • Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
Synonyms 2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol
2,5,8,11,14-Pentaoxahexadecan-16-ol
1PG
3,6,9,12,15-pentaoxahexadecanol
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
3,6,9,12,15-Pentaoxahexadecan-1-ol
14-methoxy-3,6,9,12-tetraoxa-tetradecan-1-ol
Description Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 332.3±32.0 °C at 760 mmHg
Molecular Formula C11H24O6
Molecular Weight 252.305
Flash Point 154.7±25.1 °C
Exact Mass 252.157288
PSA 66.38000
LogP -2.23
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.441
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36/37/39
HS Code 2909499000
HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%