BioBioPha
China
Product Name: Methyl 4-hydroxybenzoate
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Methyl 4-hydroxybenzoate
Price: ￥158.0/500g ￥78.0/100mg
Purity: 99.0%
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DC Chemicals Limited
China
Product Name: Methylparaben
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methylparaben
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Methylparaben
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson

99-76-3

99-76-3 structure

Name: Methyl 4-hydroxybenzoate
Chemical Name: methylparaben
CAS Number: 99-76-3
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.147
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-09-09 18:09:01
Modify Date: 2024-01-01 19:14:13
Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].

Name	methylparaben
Synonyms	methyl p-hydroxybenzoate 4-Hydroxybenzoic acid, methyl ester 4-(Carbomethoxy)phenol Mekkings M Benzoic acid, 4-hydroxy-, methyl ester Methylparaben 4-(Methoxycarbonyl)phenol Methyl parahydroxybenzoate Killitol Methyl chemosept Methyl-4-hydroxybenzoate p-Hydroxybenzoic acid methyl ester methyl para-hydroxybenzoate 4-Hydroxybenzoic Acid Methyl Ester EINECS 202-785-7 Methyl 4-hydroxybenzoate Benzoic acid, p-hydroxy-, methyl ester Nipagin 4-Hydroxy-benzoic acid methyl ester Metagin p-Hydroxybenzoic acid, methyl ester p-Hydroxybenzoic methyl ester Methyl parasept Tegosept M 4-Hydroxybenzoic acid methylester MFCD00002352 Methyl Paraben

Description	Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Phenols
References	[1]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73.

Density	1.2±0.1 g/cm3
Boiling Point	265.5±13.0 °C at 760 mmHg
Melting Point	125-128 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	116.4±12.6 °C
Exact Mass	152.047348
PSA	46.53000
LogP	1.87
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.547
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Freezing Point	131℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2450000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, methyl ester

CAS REGISTRY NUMBER :: 99-76-3

BEILSTEIN REFERENCE NO. :: 0509801

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR DVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80461 No. of Facilities: 4469 (estimated) No. of Industries: 33 No. of Occupations: 50 No. of Employees: 57029 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80461 No. of Facilities: 15369 (estimated) No. of Industries: 94 No. of Occupations: 117 No. of Employees: 590361 (estimated) No. of Female Employees: 398916 (estimated)

Hazard Statements	H412
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	UN 2769
WGK Germany	1
RTECS	DH2450000
HS Code	2918290000

Precursor 10
32122-11-5 17763-71-2 99768-12-4 67-56-1
99-96-7 123-08-0 24262-66-6 35750-24-4
133642-20-3 75915-29-6
DownStream 10
104605-71-2 110683-64-2 105960-29-0 110482-75-2
106047-17-0 106342-09-0 1090587-89-5 50909-50-7
3753-81-9 35826-59-6

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

99-76-3	35816-31-0
75919-68-5	19438-10-9
1216543-26-8	5026-62-0
362049-51-2	32122-11-5
90577-88-1	85392-27-4