Name | glutaric acid |
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Synonyms |
Iressa
Pentanedioic acid Irressat 1,5-Pentanedioate Propane-1,3-dicarboxylic acid n-Pyrotartaric acid 1,5-Pentanedioic acid 1,3-propanedicarboxylic acid EINECS 203-817-2 hydrogen glutarate Glutaric acid ZD 1839 Gefitinib 1,3-Propanedicarboxylate MFCD00004410 |
Description | Glutaric acid induces oxidative stress in brain of young rats. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 302.9±15.0 °C at 760 mmHg |
Melting Point | 95-98 °C(lit.) |
Molecular Formula | C5H8O4 |
Molecular Weight | 132.115 |
Flash Point | 151.2±16.9 °C |
Exact Mass | 132.042252 |
PSA | 74.60000 |
LogP | -1.04 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.477 |
Storage condition | 2-8°C |
Stability | Stable. Incompatible with bases, oxidizing agents, reducing agents. |
Water Solubility | 430 g/L (20 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H319 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
RTECS | MA3740000 |
HS Code | 2932999099 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2917190090 |
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Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |