1501-84-4

1501-84-4 structure

Name: Rimantadine Hydrochloride
Chemical Name: Rimantadine Hydrochloride
CAS Number: 1501-84-4
Molecular Formula: C₁₂H₂₂ClN
Molecular Weight: 215.763
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-04-19 08:00:00
Modify Date: 2024-01-02 14:39:01
Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

Name	Rimantadine Hydrochloride
Synonyms	1-(1-Adamantyl)ethylamine Hydrochloride tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride 1-(Adamantan-1-yl)ethanamine hydrochloride (1:1) a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride Roflual 1-(tricyclo[3.3.1.1]dec-1-yl)ethanamine hydrochloride (1:1) Meradan Tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride (1:1) α-Methyl-1-adamantanemethylamine hydrochloride MFCD00072023 UNII:JEI07OOS8Y a-Methyl-1-adamantanemethylamine Hydrochloride 1-(Adamantan-1-yl)ethanamine hydrochloride 1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid Alpha-Methyl-1-Adamantanemethylamine Hydrochloride 1-(1-Aminoethyl)adamantane hydrochloride Tricyclo[3.3.1.13,7]-decane-1-methanamine, .α.-methyl-, hydrochloride Rimantadine Hydrochloride 1-tricyclo[3.3.1.1]déc-1-yléthanamine chlorhydrate 1-tricyclo[3.3.1.1]dec-1-ylethanamine hydrochloride Remantadine hydrochloride

Description	Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
References	[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82. [2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 28(9),23,1982

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,798,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU4717000
HS Code	2921199090

78679-71-7

~76%

1501-84-4

Literature: US4551552 A1, ;

HS Code	2921300090
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%