Rimantadine Hydrochloride structure
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Common Name | Rimantadine Hydrochloride | ||
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CAS Number | 1501-84-4 | Molecular Weight | 215.763 | |
Density | N/A | Boiling Point | 247.8ºC at 760mmHg | |
Molecular Formula | C12H22ClN | Melting Point | 300ºC | |
MSDS | Chinese USA | Flash Point | 99.3ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Rimantadine HydrochlorideRimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2]. |
Name | Rimantadine Hydrochloride |
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Synonym | More Synonyms |
Description | Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2]. |
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Related Catalog | |
References |
Boiling Point | 247.8ºC at 760mmHg |
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Melting Point | 300ºC |
Molecular Formula | C12H22ClN |
Molecular Weight | 215.763 |
Flash Point | 99.3ºC |
Exact Mass | 215.144073 |
PSA | 26.02000 |
LogP | 4.05230 |
Vapour Pressure | 0.0251mmHg at 25°C |
Water Solubility | Freely soluble in water. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful |
Risk Phrases | R22 |
Safety Phrases | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | AU4717000 |
HS Code | 2921199090 |
~76% Rimantadine Hyd... CAS#:1501-84-4 |
Literature: US4551552 A1, ; |
Precursor 1 | |
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DownStream 2 | |
HS Code | 2921300090 |
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Summary | 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Exploring the proton conductance and drug resistance of BM2 channel through molecular dynamics simulations and free energy calculations at different pH conditions.
J. Phys. Chem. B 117(4) , 982-8, (2013) BM2 channel plays an important role in the replication of influenza virus B. However, few studies attempt to investigate the mechanism of the proton conductance in BM2 channel, as well as the drug res... |
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Cys-Loop Receptor Channel Blockers Also Block GLIC
Biophys. J. 101(12) , 2912-8, (2011) The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular has a high sequence homology to these rela... |
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[Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].
Antibiot. Khimioter. 56(3-4) , 3-9, (2011) The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pa... |
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