150436-68-3

150436-68-3 structure

Name: sodium 2-(4-methoxyphenoxy) propionate
Chemical Name: (+/-)-2-(p-methoxyphenoxy)propionic acid
CAS Number: 150436-68-3
Molecular Formula: C₁₀H₁₂O₄
Molecular Weight: 196.200
Catalog: Research Areas Metabolic Disease
Create Date: 2019-05-27 05:36:02
Modify Date: 2024-01-09 12:38:52
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].

Name	(+/-)-2-(p-methoxyphenoxy)propionic acid
Synonyms	2-(4-Methoxyphenoxy)propanoic acid PMP (±)-2-(p-Methoxyphenoxy)propionic acid UNII:K573UZ6O8U Propanoic acid, 2-(4-methoxyphenoxy)- 2-(4-Methoxyphenoxy)propionic acid

Description	Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	T1R3[1]
In Vitro	Lactisole (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。 Lactisole (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c)，而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。