sodium 2-(4-methoxyphenoxy) propionate

Modify Date: 2024-01-09 12:38:52

sodium 2-(4-methoxyphenoxy) propionate Structure
sodium 2-(4-methoxyphenoxy) propionate structure
Common Name sodium 2-(4-methoxyphenoxy) propionate
CAS Number 150436-68-3 Molecular Weight 196.200
Density 1.2±0.1 g/cm3 Boiling Point 331.6±17.0 °C at 760 mmHg
Molecular Formula C10H12O4 Melting Point N/A
MSDS N/A Flash Point 130.3±14.4 °C

 Use of sodium 2-(4-methoxyphenoxy) propionate


Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].

 Names

Name (+/-)-2-(p-methoxyphenoxy)propionic acid
Synonym More Synonyms

 sodium 2-(4-methoxyphenoxy) propionate Biological Activity

Description Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
Related Catalog
Target

T1R3[1]

In Vitro Lactisole (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。 Lactisole (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c),而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 331.6±17.0 °C at 760 mmHg
Molecular Formula C10H12O4
Molecular Weight 196.200
Flash Point 130.3±14.4 °C
Exact Mass 196.073563
PSA 55.76000
LogP 1.65
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.521

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36

 Synonyms

2-(4-Methoxyphenoxy)propanoic acid
PMP
(±)-2-(p-Methoxyphenoxy)propionic acid
UNII:K573UZ6O8U
Propanoic acid, 2-(4-methoxyphenoxy)-
2-(4-Methoxyphenoxy)propionic acid