Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Rilpivirine
Price: ￥588.0/25mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Rilpivirine(R 278474, TMC 278)
Price: $300.0/100mg $550.0/250mg $1100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Rilpivirine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Rilpivirine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

500287-72-9

500287-72-9 structure

500287-72-9 structure

Name: Rilpivirine
Chemical Name: rilpivirine
CAS Number: 500287-72-9
Molecular Formula: C₂₂H₁₈N₆
Molecular Weight: 366.418
Catalog: Biochemical Inhibitor Microbiology Reverse Transcriptase inhibitor
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-02 01:19:17
Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Name	rilpivirine
Synonyms	[3H]-Rilpivirine Edurant Rilpivirine TMC-278 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile 4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile Benzonitrile, 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]- UNII-FI96A8X663 R 278474 BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-)

Description	Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
Target	NNRTIs
In Vitro	Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
References	[1]. Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu HT, Wainberg MA, Sarafianos SG.Biochemical Mechanism of HIV-1 Resistance to Rilpivirine.J Biol Chem. 2012 Sep 6. [2]. Schafer JJ, Short WR.Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.Antivir Ther. 2012 Jul 25. [3]. Vingerhoets J, Rimsky L, Van Eygen V, Nijs S, Vanveggel S, Boven K, Picchio G.Preexisting mutations in the rilpivirine Phase III trials ECHO and THRIVE: prevalence and impact on virologic response.Antivir Ther. 2012 Sep 6. [4]. Gomes T, Juurlink DN, Mamdani MM.Comparative adherence to oxybutynin or tolterodine among older patients.Eur J Clin Pharmacol. 2012 Jan;68(1):97-9. Epub 2011 Jun 28. [5]. Azijn, Hilde et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.Antimicrobial Agents and Chemotherapy (2010), 54(2), 718-727.

Density	1.3±0.1 g/cm3
Boiling Point	634.1±65.0 °C at 760 mmHg
Melting Point	245ºC
Molecular Formula	C₂₂H₁₈N₆
Molecular Weight	366.418
Flash Point	337.3±34.3 °C
Exact Mass	366.159302
PSA	97.42000
LogP	3.63
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.665
Storage condition	Refrigerator

Hazard Codes	Xi
HS Code	2933599090

Precursor 9
873-74-5 244768-32-9 24596-19-8 3095-47-4
823786-21-6 708254-90-4 87-62-7 4102-53-8
1228671-28-0
DownStream 1
700361-47-3

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%