Rilpivirine

Modify Date: 2024-01-02 01:19:17

Rilpivirine Structure
Rilpivirine structure
 Common Name Rilpivirine
CAS Number 500287-72-9 Molecular Weight 366.418
Density 1.3±0.1 g/cm3 Boiling Point 634.1±65.0 °C at 760 mmHg
Molecular Formula C22H18N6 Melting Point 245ºC
MSDS N/A Flash Point 337.3±34.3 °C

 Use of Rilpivirine


Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

 Names

Name rilpivirine
Synonym More Synonyms

 Rilpivirine Biological Activity

Description Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Related Catalog
Target

NNRTIs
In Vitro Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
References

[1]. Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu HT, Wainberg MA, Sarafianos SG.Biochemical Mechanism of HIV-1 Resistance to Rilpivirine.J Biol Chem. 2012 Sep 6.

[2]. Schafer JJ, Short WR.Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.Antivir Ther. 2012 Jul 25.

[3]. Vingerhoets J, Rimsky L, Van Eygen V, Nijs S, Vanveggel S, Boven K, Picchio G.Preexisting mutations in the rilpivirine Phase III trials ECHO and THRIVE: prevalence and impact on virologic response.Antivir Ther. 2012 Sep 6.

[4]. Gomes T, Juurlink DN, Mamdani MM.Comparative adherence to oxybutynin or tolterodine among older patients.Eur J Clin Pharmacol. 2012 Jan;68(1):97-9. Epub 2011 Jun 28.

[5]. Azijn, Hilde et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.Antimicrobial Agents and Chemotherapy (2010), 54(2), 718-727.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 634.1±65.0 °C at 760 mmHg
Melting Point 245ºC
Molecular Formula C22H18N6
Molecular Weight 366.418
Flash Point 337.3±34.3 °C
Exact Mass 366.159302
PSA 97.42000
LogP 3.63
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.665
Storage condition Refrigerator

 Safety Information

Hazard Codes Xi
HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

[3H]-Rilpivirine
Edurant
Rilpivirine
TMC-278
4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile
4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile
Benzonitrile, 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
UNII-FI96A8X663
R 278474
BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-)
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Related Compounds: More...
Rilpivirine-d6
1312424-26-2
Rilpivirine HCl
700361-47-3
RILPIVIRINE FUMARATE SALT [1:1]
877817-88-4
Despropenenitrile Bromo Rilpivirine
374067-85-3
Chemsrc provides Rilpivirine(CAS#:500287-72-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Rilpivirine are included as well.>> amp version: Rilpivirine

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