Top Suppliers:I want be here

141543-63-7

141543-63-7 structure
141543-63-7 structure
  • Name: HA-100 hydrochloride
  • Chemical Name: 1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
  • CAS Number: 141543-63-7
  • Molecular Formula: C13H16ClN3O2S
  • Molecular Weight: 313.80300
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
  • Create Date: 2017-08-06 14:06:28
  • Modify Date: 2024-01-09 18:52:50
  • HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

Name 1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
Synonyms 5-piperazin-1-ylsulfonylisoquinoline,hydrochloride
Description HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].
Related Catalog
Target

PKG:4 μM (IC50)

PKA:8 μM (IC50)

PKC:12 μM (IC50)

MLCK:240 μM (IC50)

ROCK

In Vitro HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].
References

[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

[2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

Boiling Point 497.4ºC at 760 mmHg
Melting Point 252-254ºC
Molecular Formula C13H16ClN3O2S
Molecular Weight 313.80300
Flash Point 254.6ºC
Exact Mass 313.06500
PSA 70.68000
LogP 2.97820
Hazard Codes Xi

~%

141543-63-7 structure

141543-63-7

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
Precursor  2

DownStream  0