149409-57-4

149409-57-4 structure

Name: NE 100 hydrochloride
Chemical Name: N,N-diethyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethanamine,hydrochloride
CAS Number: 149409-57-4
Molecular Formula: C₂₃H₃₄ClNO₂
Molecular Weight: 391.97500
Create Date: 2018-06-21 21:43:01
Modify Date: 2024-02-03 15:04:15
NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].

Name	N,N-diethyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethanamine,hydrochloride
Synonyms	ne 100 NE-100

Description	NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90. [2]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9.

RIDADR	NONH for all modes of transport