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China
Product Name: Diosgenin
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Shanghai Jizhi Biochemical Technology Co., Ltd
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DC Chemicals Limited
China
Product Name: Diosgenin
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diosgenin
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Henan Tianfu Chemical Co., Ltd.
China
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512-04-9

512-04-9 structure

512-04-9 structure

Name: Diosgenin
Chemical Name: diosgenin
CAS Number: 512-04-9
Molecular Formula: C₂₇H₄₂O₃
Molecular Weight: 414.621
Catalog: Biochemical Plant extracts
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-02 11:27:09
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway.

Name	diosgenin
Synonyms	EINECS 208-134-3 3β-Hydroxy-5-spirostene Diosgenin (25R)-5-Spirosten-3β-ol MFCD00016887 DELTA 5,20A,22A,25D-SPIROSTEN-3BETA-OL

Description	Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Steroids
Target	STAT3
In Vitro	In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[1]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[2].
In Vivo	Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[3].
References	[1]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331 [2]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207. [3]. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96.

Density	1.1±0.1 g/cm3
Boiling Point	527.1±50.0 °C at 760 mmHg
Melting Point	205-208°C
Molecular Formula	C₂₇H₄₂O₃
Molecular Weight	414.621
Flash Point	272.6±30.1 °C
Exact Mass	414.313385
PSA	38.69000
LogP	5.84
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.564
Storage condition	Refrigerator
Water Solubility	chloroform: 20 mg/mL, clear, slightly yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1450000

CHEMICAL NAME :: Spirost-5-en-3-beta-ol, (25R)-

CAS REGISTRY NUMBER :: 512-04-9

BEILSTEIN REFERENCE NO. :: 0094582

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C27-H42-O3

MOLECULAR WEIGHT :: 414.69

WISWESSER LINE NOTATION :: T F5 E5 B666 HXO OUTJ A1 E1 G1 RQ H-& BT6OXTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4872 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3564 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WH1450000
HS Code	2932999099

Precursor 8
14144-06-0 6808-14-6 1061-54-7 512-06-1
468-99-5 427-28-1 1180-12-7 60478-68-4
DownStream 10
4952-68-5 50773-41-6 57-88-5 53-43-0
853-23-6 77-60-1 19057-67-1 979-02-2
1162-53-4 2857-75-2

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%