DC Chemicals Limited
China
Product Name: PDBu
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phorbol 12,13-dibutyrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

37558-16-0

37558-16-0 structure

37558-16-0 structure

Name: Phorbol-12
Chemical Name: phorbol 12,13-dibutanoate
CAS Number: 37558-16-0
Molecular Formula: C₂₈H₄₀O₈
Molecular Weight: 504.61200
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-06-19 10:00:06
Modify Date: 2024-01-02 20:35:54
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].

Name	phorbol 12,13-dibutanoate
Synonyms	PDBU PHORBOL 12,13-DIBUTYRATE,4BETA MFCD00036783 Phorbol 12,13-dibutanoate Phorbol 12,13-dibutyrate,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester Phorbol 12,13-dibutyrate

Description	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC[1]
In Vitro	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells[3].
References	[1]. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. [2]. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. [3]. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

Density	1.27g/cm3
Boiling Point	623.4ºC at 760mmHg
Molecular Formula	C₂₈H₄₀O₈
Molecular Weight	504.61200
Flash Point	199.3ºC
Exact Mass	504.27200
PSA	130.36000
LogP	2.63210
Appearance	powder \| clear, light yellow, film
Index of Refraction	1.574
Storage condition	−20°C
Water Solubility	H2O: 30 μM

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	2928
WGK Germany	3
RTECS	EK7767000
Packaging Group	II
Hazard Class	6.1(a)