Phorbol-12

Modify Date: 2024-01-02 20:35:54

Phorbol-12 structure	Common Name	Phorbol-12
	CAS Number	37558-16-0	Molecular Weight	504.61200
	Density	1.27g/cm3	Boiling Point	623.4ºC at 760mmHg
	Molecular Formula	C₂₈H₄₀O₈	Melting Point	N/A
	MSDS	USA	Flash Point	199.3ºC

Use of Phorbol-12

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].

Name	phorbol 12,13-dibutanoate
Synonym	More Synonyms

Description	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC[1]
In Vitro	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells[3].
References	[1]. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. [2]. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. [3]. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

Density	1.27g/cm3
Boiling Point	623.4ºC at 760mmHg
Molecular Formula	C₂₈H₄₀O₈
Molecular Weight	504.61200
Flash Point	199.3ºC
Exact Mass	504.27200
PSA	130.36000
LogP	2.63210
Appearance of Characters	powder \| clear, light yellow, film
Index of Refraction	1.574
Storage condition	−20°C
Water Solubility	H2O: 30 μM

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	2928
WGK Germany	3
RTECS	EK7767000
Packaging Group	II
Hazard Class	6.1(a)

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.

J. Biol. Chem. 290 , 14107-19, (2015)

Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anc...

Charge density influences C1 domain ligand affinity and membrane interactions.

ChemBioChem. 15(8) , 1131-44, (2014)

The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has emerged as a promisi...

Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.

Mol. Carcinog. 54(2) , 134-47, (2015)

Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T ce...

PDBU

PHORBOL 12,13-DIBUTYRATE,4BETA

MFCD00036783

Phorbol 12,13-dibutanoate

Phorbol 12,13-dibutyrate,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester

Phorbol 12,13-dibutyrate

DC Chemicals Limited
China
Product Name: PDBu
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phorbol 12,13-dibutyrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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